Synthesis and Characterization of 5-Fluorouracil and Polyethylene Glycol Esters as Prodrugs

Cheng Wu Li; Gang Li; Ji Cheng Zuo

doi:10.4028/www.scientific.net/AMR.287-290.1509

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 287-290Synthesis and Characterization of 5-Fluorouracil...

Synthesis and Characterization of 5-Fluorouracil and Polyethylene Glycol Esters as Prodrugs

Abstract:

A series of novel polyethylene glycol derivates was synthesized by esterification of chloroacetic acid with polyethylene glycol.The PEG-5-FU conjugates were characterized by FT-IR, ¹H-NMR and UV spectroscopy. The result showed that 5-FU was successfully connected to the ends of PEG ester. Drug content of PEG₂₀₀₀-5-FU conjugate achieved 17.4%. As the molecular weight of PEG increased, the water solubility of prodrugs improved. When the molecular weight of PEG reached 2000, the conjugate had the best water solubility and the highest drug release rate.

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Periodical:

Advanced Materials Research (Volumes 287-290)

Pages:

1509-1512

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.287-290.1509

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Online since:

July 2011

Authors:

Cheng Wu Li, Gang Li, Ji Cheng Zuo

Keywords:

5-Fluorouracil, Antineoplastic Drug, Polyethylene Glycol (PEG), Polymeric Prodrug

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