This paper presents the design method of a novel biomaterial impedance analyzer based on digital auto balancing bridge method. The system hardware mainly consists of FPGA, ADC, DACs and operational amplifiers. Many DSP algorithms such as direct digital frequency synthesis (DDS), digital phase sensitive demodulation (DPSD), digital modulation and digital filter are implemented in FPGA to realize the auto balancing function of the bridge circuit. Simulation results show that the system has good performance from low frequency to 10MHz. It is suitable for EIS application in biomaterial analysis.