This paper expatiates hydrodynamic time-domain analysis on strategic oil storage vessels in free floating condition or with dolphin-fender mooring system by means of AQWA numerical software. The results indicate that motion responses of the oil storage vessel with dolphin-fender mooring have improved significantly. The time-history of wave diffraction forces in incident wave direction are basically consistent between the free floating and moored condition. However, in vertical direction of incident wave, the diffraction wave force of the oil storage vessel in free floating condition is obviously different from that with mooring system, which is the result of the coupling interaction between dolphin and vessels. Mooring forces include fender reaction and cable tension, as for which dominate, it depend on evocable motion responses about incident wave direction.