It is not difficult to prepare self-compacting concrete (SCC) in laboratory now. The problem researchers faced is how SCC can be popularized in civil engineering. A modified densification mixture design algorithm (DMDA) is used in this study to prepare the control mixture. And on the basis of the system analysis for exist studies, 6 factors are chosen as experimental factor and 25 experiments are designed by orthogonal design experiment method. The results analysis indicates that only 3 factors are significant on SCC and their recommend value is obtained respectively. It may shed light on the application of SCC.