The study discussed the desalination effect of influence factors (operation pressure, salt concentration, pH, ionic valence and etc.) for two different types nanofiltration (NF) (DK and NF90), based on desalination NF characteristics of membrane. The results showed the same desalination characteristics of the two kinds NF that desalination performance decrease directly with NF operation pressure and salt concentration increasing. When pH value was controlled in an acidic range of 4 to 7, it could obtain both high salt removal and membrane flux in salt solution. The salt rejection sequence of two NF was NaCl <MgCl2 <Na2SO4 <MgSO4 <Na3PO4 in different valence salt neuter solution. The different desalination characteristics of two kinds NF showed that monovalent salt rejection of DK (over 35%) was lower than that of NF90 (above 85%). The multivalent salt rejection of two NF showed higher removal efficiency, with DK over 96% and NF90 over 99%.