Process Optimization of Cefradine/ Montmorillionite in Solution Intercalation
One-factor-at-a-time design and orthogonal design were used in the experimental design to optimize the process of preparation for Cefradine /Montmorillionite composites in solution intercalation. Experimental results indicate that drug initial concentration was the most significant condition for optimal preparation of composites, intercalation time and reaction temperature were not so significant. In our paper, the maximum drug load occurred at reaction temperature of 60°C with the intercalation time of 2h when the drug concentration (mass ratio of cefradine to MMT) was 2:1.
Shiquan Liu and Min Zuo
Y. Z. Zhao et al., "Process Optimization of Cefradine/ Montmorillionite in Solution Intercalation", Advanced Materials Research, Vols. 306-307, pp. 831-834, 2011