Research on the Modification of Poly(L-Lactic Acid) by Glucose via Direct Melt Polycondensation

Abstract:

Directly using L-lactic acid (L-LA) and glucose (Glu) as the starting materials, novel biodegradable material poly(L-lactic acid-co-glucose) [P(L-LA-co-Glu)] was synthesized via direct melt polycondensation. The copolymers P(L-LA-co-Glu)s at different molar feed ratios were characterized by FTIR, ¹H-NMR, GPC, DSC and XRD. All poly(L-lactic acid) modified by Glu was partly crystalline. And their M_w, T_m, and crystallinity basically increased with the increase of the molar feed ratio n(L-LA) : n(Glu). When n(Glu) : n(L-LA) was 1 : 750, the biggest Mw was 5900 Da, and all M_w could meet the requirement for drug delivery application.

• Periodical: Advanced Materials Research (Volumes 311-313)
• Pages: 1106-1109
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.311-313.1106
• Online since: August 2011
• Authors: Shi He Luo, Shi Qin Yu, Jian Xiao Li, Zhao Yang Wang
• Keywords: Biodegradable Material, Direct Melt Polycondensation (DMP), Glucose, L-Lactic Acid, Modification, Poly(lactic acid) (PLA)

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