Herbal-Loaded Multifunctional Nanocomposities as Nanocarrier for Cancer Therpy: Synthesis and Quality

Abstract:

The multifunctional nanocompoties (MFNCs) as drug release carriers are prepared by cross-linking reaction of cationic chitosan (CS) and anionic tripolyphosphate (TPP) to encapsulate Fe3O4 nanoparticles(NPs) loaded cancer therapeutic agents such as berberine (BB), KCY-24B, KCY-Tai…etc were studied. These MFNCs were characterized by fourier transform infrared spectrophotometer (FT-IR), ultra violet–visible-near infrared spectrophotometer (UV-VIS-NIR spectrophotometer), size analysis, transmission electron microscope (TEM) and field-emission scanning electron microscope (FESEM). Then we obtained here the preparation method, characterization, and capability of these efficative nanoparticles. Cell celluar uptake and distribution of MFNCs were also inspected in human colon adenocarcinoma cell lines (Colo 205).

• Periodical: Advanced Materials Research (Volumes 311-313)
• Pages: 1625-1629
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.311-313.1625
• Online since: August 2011
• Authors: Chih Wei Chou, Sheng Yueh Chang, Yung Shiu Chen, Wu Chung Su, Te Hsing Wu
• Keywords: Herbal-Loaded Chitosan, Multifunctional Nancompoties

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