The influences of inner layer′s (spacer yarn′s) pattern, surface structure of fabric, thickness, and spacer yarn′s diameter on compression resistance of warp knitted spacer fabric were investigated in the study. The compression tests involving 10 samples were carried out by TexLab Precision Instruments CT250 based on Chinese standard FZ/T01051.2-1998. The results show that inner layer′s pattern and surface structure affect the compression resistance of spacer fabric by changing the inclination angle of spacer yarn, the closer spacer yarn keep vertical, the better compression resistance of fabric. The laws of force exerted on spacer yarn followed by fabric′s thickness differ according to compression rate, the compression resistance increases as the thickness increases when the deformation of fabric is small (less than 4.90%), but decreases when the deformation is large enough (more than 19.20%). The diameter of spacer yarn has apparent effect on compression resistance, and the fabric with finer spacer yarns has lower compression resistance.