Synthesis of some Curcumin Analogues under Ultrasound Irradiation
A convenient method to synthesize curcumin and its five analogues, which were named as 1,7-diphenyl-1,6-heptadiene-3,5-dione,1,7-Bis-(4-hydroxy-phenyl)-1,6-heptadiene-3,5-dione,1,7-Bis-(4-methoxy-phenyl)-1,6-heptadiene-3,5-dione,1,7-Bis-(2-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione and 1,7-Bis-(2,3-dimethoxy-phenyl)-1,6-heptadiene-3,5-dione respectively, via the Claisen condensation of aromatic aldehyde and 2,4-pentanedione in the presence of trimethyl borate and monoethanolamine under ultrasound irradition was reported. The corresponding physical properties were characterized by IR, 1HNMR spectra and elemental analysis studies.
Xiaoming Qian and Huawu Liu
Y. J. Lei et al., "Synthesis of some Curcumin Analogues under Ultrasound Irradiation", Advanced Materials Research, Vols. 332-334, pp. 1623-1626, 2011