Preparation and Chiral Resolution Properties of L-Phenylalanine Modified Poly(NIPAAm-Co-AAc) Hydrogels

Abstract:

Poly(NIPAAm-co-AAc) hydrogels of different ratios were prepared by copolymerization and then modified with L-phenylalanine by amidation of carboxyl groups of acrylic acid. The structures of the hydrogels were identified by IR and the chiral separation experiments of hydrogels on D/L-phenylalanine were investigated. The results showed that the chiral hydrogels exhibited enantioselectivity for L-phenylalanine and the resolution capability increased with the rising of temperature and contents of L-phenylalanine groups.

• Periodical: Advanced Materials Research (Volumes 332-334)
• Pages: 1852-1855
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.332-334.1852
• Online since: September 2011
• Authors: Dan Dan Zhang, Jiao Jiao Chen, Li Chen
• Keywords: Chiral Resolution, D/L-Phenylalanine, N-Isopropylacrylamide, Temperature-Sensitive

References

[1] L.D. Taylor, L.D. Cerankowski: J. Polym. Sci: Polym. Chem. Ed. Vol.13 (1975), p.2551

[2] Y. Hirokawa, T. Tanaka: J. Chem. Phys. Vol. 81 (1984), p.6379

[3] K. Heskins, J.E. Guillet: J. Macromol. Sci. Chem. A. Vol. 2(1968): p.1441

[4] R. Yoshicla, T. Sakai, O. Tamhata: Sci. Tech. Ad. Mat. Vol. 3(2002): p.95

[5] A. Fucks, F. Gordaninejad: J. Appl. Polym. Sci. Vol. 84 (2002), p.2733

[6] Y. Okamoto, T. Nakano: Chem. Rev. Vol. 94 (1994), p.349

[7] N.M. Maier, P. Franco, W. Lindner: J. Chromatogr. A. Vol. 906 (2001), p.3

[8] E.R. Francotte: J. Chromatogr. A. Vol. 906 (2001), p.379

[9] E.L. Izake: J. Pharm. Sci. Vol. 96 (2007), p.1659