The Study of Using TiO2 Nanotube Arrays as a Drug Delivery for Alendronate

Chun Yan Wang; Xiu Feng Xiao; Dan Mao; Hai Zhen Tang; Rong Fang Liu

doi:10.4028/www.scientific.net/AMR.335-336.1469

Paper Titles

Hydrolysis of Glucose to 5-Hydroxymethylfurfural
p.1448

Preparation of Porous HA Bioceramics by Gelcasting and Pressureless Sintering
p.1454

Characteristics Analysis of Acoustic Emission Signals from Titanium under Tensile Fracture
p.1459

Recovery of Sc³⁺ from Red Mud Leaching Solution by Emulsion Liquid Membrane
p.1465

The Study of Using TiO₂ Nanotube Arrays as a Drug Delivery for Alendronate
p.1469

Cutting Parameters Optimization Based on Radial Basis Function Neural Network and Particle Swarm Optimization
p.1473

Preparation and Properties of Bacterial Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Fibers
p.1477

Research on Controllable Effects of HI Ultrasonic Radiation to Active Composition in Hippophae
p.1481

The Modification of VPO Catalyst Precursor and Characterization
p.1485

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The Study of Using TiO₂ Nanotube Arrays as a Drug Delivery for Alendronate

Abstract:

TiO₂ nanotube arrays possess regular hollow structure, large specific surface area and good biocompatibility, which are good for filling with drugs. In this paper, a vertically aligned nanotube arrays of titanium oxide was fabricated on the surface of titanium substrate in fluoride-containing electrolytes by anodization. The TiO₂ nanotube arrays were loaded with alendronate via vacuum drying method and the release of alendronate from the nanotubes were detected in phosphate buffer solution(PBS). The samples were characterized by scanning electronic microscope(SEM), X-ray diffraction(XRD), Fourier transform infrared(FTIR), Thermogravimetric analysis (TG) and visible ultraviolet spectrophotometer(UV-vis). The data showed that the release of alendronate from the nanotubes includes two stages: burst release and sustained release, the result indicated that the drug loaded in the TiO₂ nanotubes has a certain amounts of sustained-release effect.