Paper Title:
The Study of Using TiO2 Nanotube Arrays as a Drug Delivery for Alendronate
  Abstract

TiO2 nanotube arrays possess regular hollow structure, large specific surface area and good biocompatibility, which are good for filling with drugs. In this paper, a vertically aligned nanotube arrays of titanium oxide was fabricated on the surface of titanium substrate in fluoride-containing electrolytes by anodization. The TiO2 nanotube arrays were loaded with alendronate via vacuum drying method and the release of alendronate from the nanotubes were detected in phosphate buffer solution(PBS). The samples were characterized by scanning electronic microscope(SEM), X-ray diffraction(XRD), Fourier transform infrared(FTIR), Thermogravimetric analysis (TG) and visible ultraviolet spectrophotometer(UV-vis). The data showed that the release of alendronate from the nanotubes includes two stages: burst release and sustained release, the result indicated that the drug loaded in the TiO2 nanotubes has a certain amounts of sustained-release effect.

  Info
Periodical
Advanced Materials Research (Volumes 335-336)
Chapter
Chapter 10: Functional Materials
Edited by
Yun-Hae Kim, Prasad Yarlagadda, Xiaodong Zhang and Zhijiu Ai
Pages
1469-1472
DOI
10.4028/www.scientific.net/AMR.335-336.1469
Citation
C. Y. Wang, X. F. Xiao, D. Mao, H. Z. Tang, R. F. Liu, "The Study of Using TiO2 Nanotube Arrays as a Drug Delivery for Alendronate", Advanced Materials Research, Vols. 335-336, pp. 1469-1472, 2011
Online since
September 2011
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Price
$35.00
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Authors: Xiao Juan Yang, Zhang Wang, Ping Li, Yi Rong Chen, Xiu Feng Xiao
Chapter 1: Chemical Engineering and Technology, Bio and Medical Chemistry Engineering
Abstract:TiO2 nanotube arrays (TNTs) were preparation on Ti influoride containing electrolytes via anodization. Poly...
167