Application of Hollow Microneedle for Transdermal Delivery of Bovine Serum Albumin-Fluorescein Isothiocyanate Conjugate

Maleenart Petchsangsai; Nanthida Wonglertnirant; Theerasak Rojanarata; Praneet Opanasopit; Tanasait Ngawhirunpat

doi:10.4028/www.scientific.net/AMR.338.365

Paper Titles

Optimal Control of Error Performance of Planar 3-DOF Parallel Mechanism
p.343

Synthesis and Characterization of Coral-Like Micronano-SiO₂
p.350

The Welding Robot Arm Optimization Based on APDL
p.355

Synthesis of Ultrafine TiC from TiOSO₄ and Phenol–formaldehyde Resins
p.360

Application of Hollow Microneedle for Transdermal Delivery of Bovine Serum Albumin-Fluorescein Isothiocyanate Conjugate
p.365

Development on CAD System of Tri-Cone Bits Based on UG
p.369

Damage Modes Detection of Composite Laminates Using Improved Modal Strain Energy Method
p.375

First-Principles Studies on the Component Dependences of High-Entropy Alloys
p.380

Preparation and Characterization of Biocompatible Magnetic Fluids
p.384

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 338Application of Hollow Microneedle for Transdermal...

Application of Hollow Microneedle for Transdermal Delivery of Bovine Serum Albumin-Fluorescein Isothiocyanate Conjugate

Abstract:

The objective of the present study was to use hollow microneedles for enhancing the transdermal delivery of Bovine Serum Albumin (MW~66,000 Da)-Fluorescein Isothiocyanate (BSA-FITC) conjugate, a hydrophilic large molecular compound. BSA-FITC was successfully loaded into the lower epidermis as well as the superficial dermis of the skin of neonatal pig by a hollow microneedle. The higher the volume of BSA-FITC solution injected, the higher the amount and the faster the BSA-FITC release rate from skin. These release profiles of BSA-FITC solution were expressed by Fick’s law of diffusion. These results suggest the utilization of hollow microneedle to enhance transdermal delivery of protein and provide useful information for designing an effective hollow microneedle system.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volume 338)

Pages:

365-368

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.338.365

Citation:

Cite this paper

Online since:

September 2011

Authors:

Maleenart Petchsangsai, Nanthida Wonglertnirant, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat

Keywords:

Macromolecules, Microneedles, Skin Permeation, Transdermal Drug Delivery

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] Narasimha Murthy and H. N. Shivakumar, "Handbook of Non-Invasive Drug Delivery Systems" (2010), pp.1-3.

DOI: 10.1016/b978-0-8155-2025-2.10001-0

Google Scholar

[2] M.R. Prausnitz, R. Langer: Nat. Biotechnol. Vol. 26 (2008), p.1261–1268

Google Scholar

[3] M.R. Prausnitz: Advanced Drug Delivery Reviews Vol. 56 (2004), p.581–587.

Google Scholar

[4] L. Daugimont, N. Baron, G. Vandermeulen, N. Pavselj, D. Miklavcic, M.C. Jullien, G. Cabodevila, L.M. Mir, V. Pre´at: J Membrane Biol Vol. 236 (2010), p.117–125.

DOI: 10.1007/s00232-010-9283-0

Google Scholar

[5] E. Gonzalez-Gonzalez, T. J. Speaker, R. P. Hickerson, R. Spitler, M. A. Flores, D. Leake, C. H. Contag, and R. L. Kaspar, "Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD),"

DOI: 10.1038/mt.2010.126

Google Scholar

[6] W. Q. Lin, M. Cormier, A. Samiee, A. Griffin, B. Johnson, C.-L. Teng, G. E. Hardee, and P.E. Daddona: Pharmaceutical Research Vol. 18 (2001), pp.1789-1793.

DOI: 10.1023/a:1013395102049

Google Scholar

[7] N. Wonglertnirant, H. Todo, P. Opanasopit, T. Ngawhirunpat, K. Sugibayashi: Biol. Pharm. Bull. Vol. 33 (2010), p.1988—1993.

DOI: 10.1248/bpb.33.1988

Google Scholar

[8] R. F. Donnelly, M. J. Garland, D. I.J. Morrow, K. Migalska, T. Raghu Raj Singh, R. Majithiya, A. D. Woolfson: Journal of Controlled Release Vol. 147 (2010), p.333–341.

DOI: 10.1016/j.jconrel.2010.08.008

Google Scholar