Correction of Baseline Drifts due to the Pressure Changes between Attenuated Total Reflection Prism and Human Skin for Noninvasive Blood Glucose Sensing with Fourier Transform Infrared Spectroscopy

Abstract:

.For noninvasive blood sensing with attenuated total reflection (ATR)-Fourier Transform infrared spectroscopy(FTIR), the baseline of spectra human skin will drift because of the exitence of pressure changes between ATR prism and human skin . To correct the baseline drifts ,In the paper, the fingertips spectra in mid-infrared were recorded under the special conditions. A line equation was calculated using the last 14 spectra coupled with the linear regression analysis between the absorbance spectra at the 1035cm^-1 and the 950cm^-1 . And the corrected absorption intensities, after the removal of the baseline drifts, can be applied for the quantification of glucose concentrations in blood easily with the given method in the paper.

• Periodical: Advanced Materials Research (Volume 345)
• Pages: 119-123
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.345.119
• Online since: September 2011
• Authors: Dong Min Wang, Qi Peng Lu, Li Jun Yao
• Keywords: Attenuated Total Reflection, Baseline Drifts, Mid-Infrared Spectroscopy, Noninvasive Glucose Sensing

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