Baihua Lake, a man-made reservoir located in a typical plateau karstic area, is one of the five drinking water sources for Guiyang city. In the present research, the organochlorine pesticides and polychlorinated biphenyls in the muscle tissues of six fish species collected from Baihua Lake were estimated by gas chromatography/mass spectrometry (GC/MS) . The total concentration of OCPs ranged from 2.83 to 94.25 ng g-1 (dry weight), and that of PCBs ranged from ND to 4.78 ng g-1. p,p’-DDD, p,p’-DDE, γ-HCH and PCB28 were detected in the majority of the samples. However the biomagnifications of OCPs and PCBs were not significant in the selected fish from the lake.