in order to study and analysis on pressure distribution of pipeline system under the conditions of different power, to obtain the mutual influence degree between users. Through multi-storey residential pressure change exhaust system measured under the condition of three pressure changed board, the experimental results are compared and analyzed. The result of this paper obtains pressure of the mains and branch and branch speeds in different conditions. In six floors of 400 * 250 pressure changed type exhaust pipe system, no matter exhaust fan’s volume is high-end or low-end in any conditions can satisfy the exhaust requirements. Pipe internal pressure showed low - high – low.