Preparation of Mesoporous Bioglass Coated Zirconia Scaffold for Bone Tissue Engineering

Feng Lin; Cheng Yan; Wei Zheng; Wei Fan; Clayton Adam; Adekunle Oloyede

doi:10.4028/www.scientific.net/AMR.365.209

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 365Preparation of Mesoporous Bioglass Coated Zirconia...

Preparation of Mesoporous Bioglass Coated Zirconia Scaffold for Bone Tissue Engineering

Abstract:

Porous yttria-stabilized zirconia (YSZ) has been regarded as a potential candidate for bone substitute due to its high mechanical strength. However, porous YSZ is biologically inert to bone tissue. It is therefore necessary to introduce bioactive coatings onto the walls of the porous structures to enhance its bioactivity. In this study, porous YSZ scaffolds were prepared using a replication technique and then coated with mesoporous bioglass due to its excellent bioactivity. The microstructures were examined using scanning electron microscopy and the mechanical strength was evaluated via compression test. The biocompatibility and bioactivity were also evaluated using bone marrow stromal cell (BMSC) proliferation test and simulated body fluid test.

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Periodical:

Advanced Materials Research (Volume 365)

Pages:

209-215

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.365.209

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Online since:

October 2011

Authors:

Feng Lin, Cheng Yan, Wei Zheng, Wei Fan, Clayton Adam, Adekunle Oloyede

Keywords:

Compressive Strength, Mesoporous Bioglass, Porous Structure, Scaffold, Zirconia (YSZ)

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