In the service of sliding isolated structure, the slip component damage degree determines the safety of sliding isolated structure. The seismic response analysis about a sliding isolated frame structures was obtained by the finite element analysis software SAP2000 at various loads and compared with the traditional structure. Seismic response differences between slip component of the different forms and number damage was studied. According to Teflon invalid and the displacement-limited of energy dissipation component invalid, the impact of seismic response owing to slip component damage was analyzed. It will provide a reference for the isolated building design, the effective maintenance and damage detection.