Preparation and Degradation Properties of Hydroxyethyl Chitosan-g-Poly(D,L-Lactide) Copolymers

Bing Hong Luo; Jian Hua Li; Wan Xu; Chang Ren Zhou

doi:10.4028/www.scientific.net/AMR.457-458.308

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 457-458Preparation and Degradation Properties of...

Preparation and Degradation Properties of Hydroxyethyl Chitosan-g-Poly(D,L-Lactide) Copolymers

Abstract:

The goal of the present study was to investigate the degradation of hydroxyethyl chitosan-g-poly(D,L-lactide) (HECS-g-PDLLA) copolymers in vitro. For this purpose, HECS-g-PDLLA copolymers were firstly synthesized by bulk ring-opening polymerization with different n_D,L-lactide:n_{aminoglucoside} feed ratio. Then, a series of poly(D,L-lactide), chitosan and HECS-g-PDLLA copolymers films were prepared by solution casting method, and their degradation were carried out in vitro in saline water at 37 °C. The degradation properties were investigated by measurement of pH value, weight loss, and changes in the composition and structure of the HECS-g-PDLLA copolymers films with time. Results showed that the degradation of the HECS-g-PDLLA copolymers occurred firstly on the poly(D,L-lactide) side chains. The degradation rate of the graft copolymers obviously faster than that of CS, and can be controlled by changing the value of n_D,L-lactide:n_{aminoglucoside}. Due to the alkalinity of CS, the pH value of saline water for HECS-g-PDLLA copolymers degradation higher than that of PDLLA.

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Advanced Materials Research (Volumes 457-458)

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308-313

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.457-458.308

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Online since:

January 2012

Authors:

Bing Hong Luo, Jian Hua Li, Wan Xu, Chang Ren Zhou

Keywords:

Degradation Properties, Graft Copolymer, Hydroxyethyl Chitosan, Poly(D,L-lactide)

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