In Vitro and In Vivo Immunomodulatory Activities of an Acidic Polysaccharide from Gracilaria lemaneiformis

Yan Li Fan; Wen Hang Wang; Hong Shuo Chen; Nian Liu; An Jun Liu

doi:10.4028/www.scientific.net/AMR.468-471.1941

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 468-471In Vitro and In Vivo Immunomodulatory Activities...

In Vitro and In Vivo Immunomodulatory Activities of an Acidic Polysaccharide from Gracilaria lemaneiformis

Abstract:

The effects of an acidic polysaccharide from Gracilaria lemaneiformis (GLSPs) on the immunomodulation in vitro and in vivo were investigated. It was shown that GLSPs with different concentrations significantly promoted the splenocyte proliferation and macrophage phagocytosis in vitro. In addition, GLSPs also remarkably enhanced the splenocyte proliferation induced by ConA or LPS in mice, notably improved the macrophage phagocytosis towards neutral red, and increased the percentages of CD3+ and CD4+ cells in peripheral blood of mice. The results suggested that GLSPs has significant effect on immunomodulation, and may have biomedical material applications and potential use in stimulating the immune system.

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Periodical:

Advanced Materials Research (Volumes 468-471)

Pages:

1941-1945

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.468-471.1941

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Online since:

February 2012

Authors:

Yan Li Fan, Wen Hang Wang, Hong Shuo Chen, Nian Liu, An Jun Liu

Keywords:

Gracilaria lemaneiformis, Immunomodulatory Activity, Macrophage Phagocytosis, Polysaccharide, Splenocyte Proliferation

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