The effect of Ge and oxygen content on microstructural formation and mechanical properties of Ti-Nb alloys were investigated in order to design a desirable Ti based alloy through casting process. Three phase mixtures consisting of bcc-structured β phase, orthorhombic structured α" phase and intermediate ω phase were found depending on Nb, Ge, oxygen content in the present alloy system. The volume fraction of α" phase and ω phase decreased with increasing Ge or oxygen content. This microstructural information may indicate that both Ge and oxygen act to increase the stability of β phase rather than α" phase in metastable β-Ti based alloys prepared by water quenching. Elastic modulus values were sensitive to phase stability of constituent phases.