Different pH-Values of Release Medium Influence the Drug Release from PTX-PCL Microspheres

Li Li Ruan; Da Xin Wang; You Wei Zhang; Jiong Xin Zhao; Xiu Fang Zhang; Nan Liang Chen

doi:10.4028/www.scientific.net/AMR.482-484.2605

Paper Titles

Density-Functional Theory Study of Ce@C₈₂
p.2577

Investigation on the Rheological Behavior of PA1010/POE/OMMT Nanocomposites
p.2582

Experimental Study on the Relationship between Carrier Gas Temperature and Entrainment Characteristics of Ultrafine Silicon Powder in Fluidized Bed
p.2587

The Study of Building Indoor and Outdoor Wind Environment
p.2592

Research on Intelligent Extension Technology for Curves Based on Trend Extrapolation
p.2596

Design of the Temperature Control System of the Giant Magnetostrictive Actuator
p.2600

Different pH-Values of Release Medium Influence the Drug Release from PTX-PCL Microspheres
p.2605

Preparation of S-F-Codoped Titania Nanotubes Electrode and its Photoelectrocatalytic Properties
p.2609

Some Physical Properties of Cassava Concerned in Machine Design
p.2613

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 482-484Different pH-Values of Release Medium Influence...

Different pH-Values of Release Medium Influence the Drug Release from PTX-PCL Microspheres

Abstract:

In this paper we study in vitro release of paclitaxel-loade polycaprolactone sustained-release microspheres. Different pH values release medium is used to simulate pH conditions in different parts of body, and determination the paclitaxel in Microspheres by High Performance Liquid Chromatography according Chinese Pharmacopoeia 2010. The experimental results indicate that the microspheres release rates of same drug loading content in buffer solution of pH 7.35 is the fastest, and in the pH 1.2 is the slowest. The drug release behavior according to the first-order model and it is not affected by drug loading rate of microspheres. The prepared paclitaxel-loade polycaprolactone sustained-release microspheres has good sustained release effect in different release media, and the results can provide references for further study of in vivo release.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 482-484)

Pages:

2605-2608

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.482-484.2605

Citation:

Cite this paper

Online since:

February 2012

Authors:

Li Li Ruan, Da Xin Wang, You Wei Zhang, Jiong Xin Zhao, Xiu Fang Zhang, Nan Liang Chen

Keywords:

Different pH-Values, Micro-Sphere, Paclitaxel, Polycaprolactone

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] N. Vidensek, P. Lin and A. Cumpbel. Taxol content in bark, wood root, leaf,twiy, and seedling from severaling from several taxus species. J Nat Prod, 1990, 53(6):1609~1610.

DOI: 10.1021/np50072a039

Google Scholar

[2] E. K. Rowinsky, N. Onetto, R. M. Canetta. Taxol:the first of the taxanes, an important new class of antitumor agents. Semin Oncol. 1992, 19(6):646~662.

Google Scholar

[3] Z. T. Shen, M. Yang, L. X. Yu. Therapeutic Effects of Thermosensitive micell of PTX on the Human Ovarian Carcinoma Transplanted Subcutaneously in Nude Mice[J], medical graduates college journal,2007,20(10): 1026-1029.

Google Scholar

[4] Kun N, Taebum L, Kun H et al. Self-assembled nanoparticles of hydrophobically modified polysaccharide bearing vitamin H as a targeted anti-cancer drub delivery system[J]. Eur J Pharm Sci, 2003(18): 165-173.

DOI: 10.1016/s0928-0987(02)00257-9

Google Scholar

[5] K. Aboustakis, A. Beletsi, etal.PLGA-mPEG nanoparticles of cisplatin: invitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties (J). J Cont Res, 2002, 79(1-3):123-135.

DOI: 10.1016/s0168-3659(01)00530-2

Google Scholar