Development of Bio-Rapid Prototyping System for Fabricating Bone Scaffold Using Thermal-Sensitive Biopolymer

Abstract:

The paper aims to develop a bio-rapid prototyping system based on air pressure-aided deposition technique for fabricating scaffolds with pore size in the range of 50 to 420 µm. The material used are thermal-sensitive polymers consisting of poly(ethylene glycol) and poly(-caprolactone), and synthesized with different molecular weights for investigating the viscosity effect on deposition stability in regarding to varying scanning speed. The experimental results show that at the molecular weight of 10,000, the molten form can be stably deposited through a heating nozzle at an air pressure of 0.3 MPa and no crack occurs after it solidifies. The scaffolds with mean pore size of 420 µm (porosity 89%) were fabricated and its average compressive strength was 9.28 MPa. The study also suggested that the developed bio-rapid prototyping system is suitable for fabricating micro-porous cellular scaffold, especially for thermal-sensitive copolymers.

• Periodical: Advanced Materials Research (Volumes 488-489)
• Pages: 985-990
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.488-489.985
• Online since: March 2012
• Authors: Yo Yu Chen, Cho Pei Jiang, Chang Cheng Chen
• Keywords: Biopolymer, Deposition, Rapid Prototyping (RP), Scaffold

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