Synthesis and Characterization of Polyesters Containing 5-Fluorouracil in the Main Chain

Jun Chang; Cheng Wu Li; Gang Li

doi:10.4028/www.scientific.net/AMR.499.99

Paper Titles

Structure and Properties of Composite Films of Cellulose and Chitosan from Ionic Liquid
p.80

Study of the Preparation and Degradable Characteristics of CaCO₃-PE Film
p.85

Surface Properties of UHMWPE Fiber after Low Temperature Argon-Plasma Treatment
p.90

Synthesis and Characterization of Novel PCA-PEG-PCA Triblock Copolymer
p.95

Synthesis and Characterization of Polyesters Containing 5-Fluorouracil in the Main Chain
p.99

Synthesis of Poly(Urethane-Urea)s from Polycarbonate Macrodiols and IPDI with the Addition of Derivant of Propylene Carbonate
p.104

The Effect of Fatty Acid on Phase Behaviors of Tween 80/bmimPF₆/toluene Microemulsions
p.108

The Electrochemical Performance of Carboxymethyl Cellulose with Different DS as a Binding Material in Lithium Batteries
p.114

Design of Rupture Strength Based on Confidence Level of HK40 Steel
p.123

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 499Synthesis and Characterization of Polyesters...

Synthesis and Characterization of Polyesters Containing 5-Fluorouracil in the Main Chain

Abstract:

A series of polyesters containing 5-fluorouracil in the main chain were prepared by reacting potassium salt of 5-fluorouracil with different molecular weight ω-chloroalkyl chloroacetyl esters.The copolymers were characterized by FT-IR, ¹H-NMR, VPO and UV spectroscopy. The drug release profile in vitro of the copolymers were studied, the results showed prodrug could slow release 5-FU or 5-FU units in different solution, they may be likely to become potential antitumor prodrug.

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Periodical:

Advanced Materials Research (Volume 499)

Pages:

99-103

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.499.99

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Online since:

April 2012

Authors:

Jun Chang, Cheng Wu Li, Gang Li

Keywords:

5-Fluorouracil, Antineoplastic Drug, Polyester, Polymeric Prodrug

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References

[1] Zhu Kaling, Tang Guping,Chen Quqi, Zhang Xiaodong,et.al,Preparation of 5-Fluorouracil-Poly-α,β(2-Hydroxyethyl)-dl-Asparamide and In-vivo Release in Rabbit[J]. Acta Pharmaceutica Sinica.,1998，33（12）：906～909

Google Scholar

[2] Fang jun, Huang Farong, Guo Hongmei, Lin Mingtao, et.al.,Investigation on the Biodegradability of Aliphatic Polyesters and Copolyesters[J]. Journal of Functional Polymer.,2003，16（6）：191～196.

Google Scholar

[3] Ikada Y, Tsuji H. Biodegradable Polyesters for Medical and Ecological Applications[J]. Macromol. Rapid Commun.,2000,21:117

DOI: 10.1002/(sici)1521-3927(20000201)21:3<117::aid-marc117>3.0.co;2-x

Google Scholar

[4] A.L Andrady. Assessment of Environmental Biodegradation of Synthetic Polymers[J]. J Macro Sci Rev:Macromol Chem Phys.,1994,C34(1):25～29

Google Scholar

[5] Luo Xuangan, Zhuo Renxi, Li Manqing, Studies of the Synthesis and Antitumor Activity of 5-Fluorouracil Derivatives Containing D-Amino Glucose Residue[J]. Chemical Journal of Chinese Universities.,1996，17（9）：1416～1420

Google Scholar