Magnesium Stearate as Anti-Tacking Agent in Acrylic Polymer Films Intended for Gas-Entrapped Floating Delivery System

Worawut Kriangkrai; Satit Puttipipatkhachorn; Pornsak Sriamornsak; Thaned Pongjanyakul; Srisagul Sungthongjeen

doi:10.4028/www.scientific.net/AMR.506.497

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 506Magnesium Stearate as Anti-Tacking Agent in...

Magnesium Stearate as Anti-Tacking Agent in Acrylic Polymer Films Intended for Gas-Entrapped Floating Delivery System

Abstract:

In development of effervescent-based floating tablets, acrylic polymer is used to prepare a gas-entrapped membrane of the system. The tackiness of this acrylic polymer film causes tablet agglomeration, leading to failure in floatation. Thus, the aim of this study was to investigate the effect of magnesium stearate (MS) used as anti-tacking agent on mechanical and wetting properties of the acrylic polymer (Eudragit^® RL 30D) films. Incorporating MS resulted in the films with a slightly lowered puncture strength, a highly lowered elongation and an increased contact angle. These results indicated that flexibility and wettability of these films were reduced by addition of MS. Furthermore, the film tackiness measurement by peel test showed that 5% (w/w) of MS could significantly decrease the tackiness of the films. It was demonstrated that MS was a promising candidate to be used as an anti-tacking agent for effervescent-based floating tablets.

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Periodical:

Advanced Materials Research (Volume 506)

Pages:

497-500

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.506.497

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Online since:

April 2012

Authors:

Worawut Kriangkrai, Satit Puttipipatkhachorn, Pornsak Sriamornsak, Thaned Pongjanyakul, Srisagul Sungthongjeen

Keywords:

Anti-Tacking Agent, Effervescent-Based Floating Tablets, Eudragit^® Rl 30D, Magnesium Stearate, Mechanical Property, Wettability

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