Synthesis and Biological Activities of Chalcones Derived from Nitroacetophenone

Xiao Yang Qiu; Su Zhi Li; An Ran Shi

doi:10.4028/www.scientific.net/AMR.518-523.255

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 518-523Synthesis and Biological Activities of Chalcones...

Synthesis and Biological Activities of Chalcones Derived from Nitroacetophenone

Abstract:

A series of nitrochalcones (compounds 1-10) were synthesized by reacting appropriate nitroacetophenones and suitable benzaldehydes. The synthesized products were evaluated for their cytotoxic, antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities in vitro. Among the compounds tested, (E)-3-(4-fluorophenyl)-1-(3-nitrophenyl)- prop-2-en-1-one (10) showed the favorable in vitro cytotoxic activity against human nasopharyngeal epidermoid tumor cell line KB, and (E)-3-(2-methoxyphenyl)-1-(3-nitrophenyl)prop-2-en-1-one (8) showed the strongest antimicrobial activity with MIC of 20 μg/mL against P. fluorescence.

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Periodical:

Advanced Materials Research (Volumes 518-523)

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255-260

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.518-523.255

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Online since:

May 2012

Authors:

Xiao Yang Qiu, Su Zhi Li, An Ran Shi

Keywords:

Antimicrobial Activity, Chalcone, Cytotoxic Activity, Structure-Activity Relationship

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