Green Synthesis of Phenytoin Sodium

Ting Ting Du; Jing Fen Li; Li Jing Min

doi:10.4028/www.scientific.net/AMR.518-523.3917

Paper Titles

Study on Intelligent Pulp Consistency Control Strategies
p.3899

Thermal Stability and Kinetic Analysis of Xanthoceras sorbifolia Polysaccharide
p.3904

A Green Route to Mass Production of Anhydrous Triammonium Citrate
p.3908

Experimental Study on Water Purification by Combination Processes of KMnO₄ Pre-Oxidation and Flotation-Sedimentation Tank
p.3912

Green Synthesis of Phenytoin Sodium
p.3917

Optimization of Hydroxyropylation Conditions and Property of Acid-Modified Hydroxypropyl Pueraria Lobata Starch
p.3921

Study on Extraction Technology of the Pigment from Spinach
p.3931

Application of Optimization Algorithm for Ceramic Formulations
p.3938

Catalyzing Synthesis of Chiral Nitrendipine
p.3943

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 518-523Green Synthesis of Phenytoin Sodium

Green Synthesis of Phenytoin Sodium

Abstract:

In this study, benzaldehyde was reacted with benzoin condensation, oxidation and cyclization reaction to product phenytoin sodium under the supersonic wave radiation. In the condensation reaction, non-toxic vitamin B1 was used as a reactor instead of highly toxic cyanide on pH=9 at 70 oC. After that, FeCl3 • 6H2O was used as oxidant instead of concentrated nitric acid under the mild conditions. The results were that the yield of phenytoin sodium was up to 56.8%. There were many advantages in this improved synthesis method such as shorter reaction time, higher product purity, lower environmental pollution and higher product yield.

You might also be interested in these eBooks

Advances in Environmental Science and Engineering

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 518-523)

Pages:

3917-3920

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.518-523.3917

Citation:

Cite this paper

Online since:

May 2012

Authors:

Ting Ting Du, Jing Fen Li, Li Jing Min

Keywords:

FeCl₃ • 6H₂O, Phenytoin Sodium, Supersonic Wave, Vitamin B1

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] W. J. Tian, J. Yuan, R. Zhang, et al: The summarize of clinical application of Phenytoin Sodium. Strait Pharmaceutical Journal Vol. 11( 2007), pp.74-76

Google Scholar

[2] J. C. Feng and L.G. Mai: Preparation of Phenytoin Sodium. Journal of Tianjin Normal University (Natural Science Edit ion) Vol. 20( 2000), pp.70-72

Google Scholar

[3] L. J. Li, J. Zhang and H. L. Chen: The synthesis route improvements of Phenytoin Sodium. Hebei Chemical Engineering and Industry Vol. 6(2004), pp.40-41

Google Scholar

[4] J. J. Deng, T. T. Li and S. L. You: The synthesis route improvements of Phenytoin Sodium. Inner Mongol Journal of Traditional Chinese Medicine Vol. 5(2008), pp.46-47

Google Scholar

[5] Q. Chen, Z. L. Yuan and H. X. Wu: Benzoin condensation with supersonic as promoter. Shanghai Chemical Industry Vol. 30(2005), pp.19-21

Google Scholar

[6] J. Nulty Mc, J. A. Steere and S. Wolf: The ultrasound promoted knoevenagel condensation of aromatic aldehydes . Tetrahedron Letters Vol. 39(1998), pp.8013-8016

DOI: 10.1016/s0040-4039(98)01789-4

Google Scholar

[7] Tianjin University: Guide of pharmaceutical engineering experiment (Chemical Industry Press, Tianjin 2005)

Google Scholar