Catalyzing Synthesis of Chiral Nitrendipine

Abstract:

This paper describes the chiral synthesis of R-2,6-dimethyl-4-(3-nitro phenyl)-1,4- dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester (R-Nitrendipine) using chiral phase transfer catalyst. The structure of the obtained nitrendipine crystals was determined with single crystal X-ray diffraction. The crystal is monoclinic, with the space group of P21/c and unit cell constants of a=8.8577(15), b=15.581(3), c=12.999(2)Å, β=92.458(4)°, V=1792.3(5)Å3, Z=4, Dc =1.335g/cm3, F(000)=760. X-ray analysis reveals that the product is a chiral nitrendipine with R-configuration of the dihydropyridine ring. And measurement of polarimeter reveals that the synthesized nitrendipine is a chiral molecular.

• Periodical: Advanced Materials Research (Volumes 518-523)
• Pages: 3943-3946
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.518-523.3943
• Online since: May 2012
• Authors: Jian Yi Wu, Li Zhang, Li Ling Cai, Yang Zhang
• Keywords: 1,4-Dihydro-Pyridine Derivatives, Chiral Nitrendipine, Crystal Structure, Phase Transfer Catalyst

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