Synthesis and Characterization of a Novel Folate-Conjugated Themoresponsive Micelles

Jing Jin; Jian Peng Xue; Si Si Cui; Jie Cao; Dong Yin Zhang; Yue Qing Gu

doi:10.4028/www.scientific.net/AMR.529.555

Paper Titles

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Synthesis and Characterization of a Novel Folate-Conjugated Themoresponsive Micelles
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 529Synthesis and Characterization of a Novel...

Synthesis and Characterization of a Novel Folate-Conjugated Themoresponsive Micelles

Abstract:

In this study, a amphiphilic copolymer, poly ((N-isopropylacrylamide)-co-acrylamide-co- (octadecylacrylate)-co-(Falate-(polyethyleneglycol)-(acrylicacid)))(P(NIPA-co-AAm-co-ODA-co-FPA)) micelles was synthesized by free radical random copolymerization. The obtained amphiphilic copolymers were self-assembled into micelles, which exhibited thermally sensitivity. LCST of the micelles was detected by uv-vis spectrophotometer. The diameter and morphology of micelles were determined by laser particle size analyzer (LPSA) and transmittance electron microscope (TEM), respectively. The micelle with a diameter of 60 nm and LCST of 40 oC was obtained by utilizing of ODA and the feed ratio of NIPA and AAm, respectively, which is satisfied for drug delivery in living body. The maximum DLC was achieved with the amount of ODA (180mg).

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Periodical:

Advanced Materials Research (Volume 529)

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555-559

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.529.555

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Online since:

June 2012

Authors:

Jing Jin, Jian Peng Xue, Si Si Cui, Jie Cao, Dong Yin Zhang, Yue Qing Gu

Keywords:

Folate, Micelle, Thermally Responsive, Tumor Targeting.

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