Preparation and Characterization of Hydroxycamptothecin-Loaded Poly(D,L-lactic acid) Nanoparticles with High Drug Loading Capacity

Zhen Qing Hou; Shui Fan Zhou; Fei Cui; Yi Xiao Hang; Yun Feng Yi

doi:10.4028/www.scientific.net/AMR.531.503

Paper Titles

Synthesis of the Thermoelectric Thin Films of Ca₃Co₄O₉ and Ca₃Co₂O₆ Using Pulsed-Laser Deposition Techniques
p.484

The Application of Organic (PVDF) Tubular Membrane on the Treatment of Catering Sewage
p.489

Preparation of SiO₂ Aerogel Supported Nano-TiO₂ Photocatalysts for Removing Rhodamine B in the Waste Water
p.494

Effect of Alginate and Cell Suspension on Viable Counts and Efficacy of Entrapment of Encapsulated B. bifidum BB28
p.499

Preparation and Characterization of Hydroxycamptothecin-Loaded Poly(D,L-lactic acid) Nanoparticles with High Drug Loading Capacity
p.503

Basicity, Water Solubility and Intrinsic Viscosity of Carboxymethyl Chitosan as a Biofunctional Material
p.507

Epoxy Modified with TDI to Cure Active Hydrogen Groups: Synthesis and Characterization
p.511

Kinetics of Ethylenediamine Wastewater Oxidation in Supercritical Water
p.516

Study on Analysis and Assessment of Acanthopanax senticosus from China and Korea with FT-IR
p.520

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 531Preparation and Characterization of...

Preparation and Characterization of Hydroxycamptothecin-Loaded Poly(D,L-lactic acid) Nanoparticles with High Drug Loading Capacity

Abstract:

Hydroxycamptothecin (HCPT) loaded PLA nanoparticles were prepared by a facile dialysis method. Three main influential factors, PLA concentration, ratio of HCPT to PLA (wt/wt), dialysis bags with different molecule weight cutoff, were evaluated using an orthogonal design, gave the nanoparticles with an average diameter of approximately 226.8 nm and fine drug loading content (5.16%, w/w). The in vitro drug release studies exhibited a slow and prolonged release profile over 30 days. It is concluded that the new method to prepare HCPT-PLA nanoparticles resulted in improved formulation characteristics including small size, high drug loading capacity, and long sustained drug release.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volume 531)

Pages:

503-506

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.531.503

Citation:

Cite this paper

Online since:

June 2012

Authors:

Zhen Qing Hou, Shui Fan Zhou, Fei Cui, Yi Xiao Hang, Yun Feng Yi

Keywords:

Dialysis, High Entrapment Efficiency, Hydroxycamptothecin (HCPT), Nanoparticle, Poly D,L-Lactic Acid (PLA)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] M. E. Wall, M. C. Wani, C. E. Cook, K.H. Palmer, A. T. McPhail and G. A. Sim: J. Am. Chem. Soc Vol. 88(1966), p.3888–3890.

Google Scholar

[2] T.G. Burke and Zihou Mi: J. Med. Chem Vol. 37(1994), pp.40-46.

Google Scholar

[3] R.B. Greenwald, Y. H. Choe and Dechun Wu: Bioorg. Med. Chem. Lett Vol. 13 (2003), P. 577-580.

Google Scholar

[4] B. Ertl, P. Platzer, M. Wirth and F. Gabor: J. Control. Release Vol. 61(1999), pp.305-317.

Google Scholar

[5] A. Shenderova, T. G. Burke and S. P. Schwendeman: Pharm. Res Vol. 16(1999), pp.241-248.

Google Scholar

[6] M. Berrada, A. Serreqi, F Dabbarh, A. Owusu, A. Gupta and S. Lehnert : Biomaterials Vol. 26(2005), pp.2115-2120.

DOI: 10.1016/j.biomaterials.2004.06.013

Google Scholar

[7] J. Williams, R. Lansdown, R. Sweitzer, M. Romanowski, R. LaBell, R. Ramaswami and E. Unger: J. Control. Release Vol. 91(2003), pp.167-172.

Google Scholar

[8] R Cortesi, E Esposito, A Maietti, E Menegatti and C Nastruzzi: Int. J. Pharm Vol. 159(1997), pp.95-103.

Google Scholar

[9] A. Lalloo, P. Chao, P. Hu, S. Stein and P. J. Sinko: J. Control. Release Vol. 112(2006), pp.333-342.

Google Scholar

[10] S. Swaminathan, L. Pastero , L. Serpe, F. Trotta, P. Vavia, D, Aquilano, M. Trotta, G.P. Zara and R. Cavalli: Eur. J. Pharm. Biopharm Vol. 74(2010), pp.193-201.

DOI: 10.1016/j.ejpb.2009.11.003

Google Scholar

[11] J. l. Wang, R. Wang and L.B. Li: J. Colloid. Interface. Sci Vol. 336(2009), pp.808-813.

Google Scholar

[12] K. M Tyner, Scott R Schiffman and E. P Giannelis: J. Control. Release Vol. 95(2004), pp.501-514.

Google Scholar

[13] L.Y. Zhang, M. Yang, Q. Wang, Y. L, R. Guo, X. Q Jiang, C. Z Yang and B. Liu: J. Control. Release Vol. 119(2007), pp.153-162.

Google Scholar