Research on Refining Process of Synthetic Folic Acid

Xue Song Liang; Chao Hua Ma; Pei Xin Li; Xiao Lian Liu; Feng Qing Zhao

doi:10.4028/www.scientific.net/AMR.549.74

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 549Research on Refining Process of Synthetic Folic...

Research on Refining Process of Synthetic Folic Acid

Abstract:

This article is mainly to investigate the factors on the refining process of folic acid. The appropriate refining process (complex refining combined acid followed by alkali treatment) was proposed. The synthetic crude folic acid was treated firstly with sulfuric acid with the concentration of 30%, then re-purified with sodium hydroxide to give folic acid with the purity of 97% and total yield of 51.3%. Higher temperature (80-100°C) is desired for the crystallization of folic acid. The product treated in this process meets the requirements of CP, USP and BP.

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Periodical:

Advanced Materials Research (Volume 549)

Pages:

74-77

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.549.74

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Online since:

July 2012

Authors:

Xue Song Liang, Chao Hua Ma, Pei Xin Li, Xiao Lian Liu, Feng Qing Zhao

Keywords:

Folic Acid, Process, Purification

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