Design and Preparation of a Bioresponsive Hydrogel for Biomedical Application as a Wound Dressing

Abstract:

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In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4-cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m-2 hr-1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.

Info:

Periodical:

Advanced Materials Research (Volumes 55-57)

Main Theme:

Edited by:

Tawee Tunkasiri

Pages:

681-684

DOI:

10.4028/www.scientific.net/AMR.55-57.681

Citation:

C. Witthayaprapakorn et al., "Design and Preparation of a Bioresponsive Hydrogel for Biomedical Application as a Wound Dressing", Advanced Materials Research, Vols. 55-57, pp. 681-684, 2008

Online since:

August 2008

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Price:

$35.00

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