Ultrastructural Characterization of Liposomes Using Transmission Electron Microscope

Prukswan Chetanachan; P. Akarachalanon; D. Worawirunwong; Pisutti Dararutana; A. Bangtrakulnonth; M. Bunjop; S. Kongmuang

doi:10.4028/www.scientific.net/AMR.55-57.709

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Ultrastructural Characterization of Liposomes Using Transmission Electron Microscope
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 55-57Ultrastructural Characterization of Liposomes...

Ultrastructural Characterization of Liposomes Using Transmission Electron Microscope

Abstract:

A liposome is a spherical vesicle composed of phospholipids and cholesterol bilayer membrane and contains a core of aqueous solution. Liposomes are polymeric nanoparticles used for drug delivery due to their unique properties. It can carry both hydrophobic and hydrophilic molecules. In this study, we showed the benefit of using transmission electron microscope (TEM) with negative staining technique to investigate the morphology of liposomes produced by thin film method. At the same magnification of micrograph results, we could see the multilamellar vesicles of liposomes in various figures and different sizes.