An Efficient Process for the Synthesis of N,N′-Diphenylpiperazine and its Formylation

Xiang Wen Kong; Xiao Pu Liu; En Tao Zhou; Jing Zhang

doi:10.4028/www.scientific.net/AMR.550-553.32

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 550-553An Efficient Process for the Synthesis of...

An Efficient Process for the Synthesis of N,N′-Diphenylpiperazine and its Formylation

Abstract:

An efficient process has been developed for the synthesis of N,N′-Diphenylpiperazine and its formyl derivative. N,N′-Diphenylpiperazine was prepared from aniline with tris(2-chloro ethyl)phosphate as an excellent alkylating reagent at a high yield (90.86%), which gave N,N′- bis(p-formylphenyl) piperazine by Vilsmeier-Haack reaction in a good yield of 86.70%. Particularly, the purity of products and the reaction progress were monitored by simple and reliable thin-layer chromatography (TLC) methods on glass-backed GF254 silica gel plate. The structure of all the products was confirmed by their melting points, spectral data (IR, 1H-NMR).

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Periodical:

Advanced Materials Research (Volumes 550-553)

Pages:

32-35

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.550-553.32

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Online since:

July 2012

Authors:

Xiang Wen Kong, Xiao Pu Liu, En Tao Zhou, Jing Zhang

Keywords:

End Point Control, N,N′-Bis(p-Formylphenyl)Piperazine, N,N′-Diphenylpiperazine, Thin-Layer Chromatography

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