The Study of Interference with Ruyanneixiao Cream on Hemorheology and Mammary Microcirculation of Mammary Precancer Rats

Abstract:

Objective: to probe the interference of Ruyanneixiao cream for hemorheology and mammary microcirculation of mammary precancer rats. Methods: 48 virginal female SD rats were randomly allocated into 6 groups, A: Blank control group (8); B: Mammary precancer model group (8); C: Tamoxifen (TAM) group (8); D: High dose group of Ruyanneixiao cream (8); E: Middle dose group of Ruyanneixiao cream (8); F: Low dose group of Ruyanneixiao cream (8). The changes of hemorheology and mammary microcirculation were recorded when the rats were executed after 60d. Result: compared with the Blank control group, the whole blood viscosity and plasma viscosity of mammary precancer model group was higher (P<0.05) and the perfusion of mammary microcirculation was lower (P<0.01). Compared with mammary precancer model group, the hemorheological parameters and perfusion of mammary microcirculation of each dose group of Ruyanneixiao cream were improved (P<0.05). Conclusion: Ruyanneixiao cream can improve the status of hemorheology, increase the perfusion of mammary microcirculation. And it may be one of mechanism to treat and prevent mammary precancer disease.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 1789-1793
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.1789
• Online since: July 2012
• Authors: Gui Juan Zhang, De Hui Li, Rui Liao, Bi Zhu Tan, Yu Bin Liu, Yi Ma, Su Yi Zhang, Min Ma, Xiao Ting Zeng, Yi Min Lin, Zhuo Long Peng
• Keywords: Hemorheology, Mammary Precancer, Microcirculation, Ruyanneixiao Powder

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