Evaluation of Anti-Diabetic Activities of Hovenia Dulcis Thunb

Abstract:

Hovenia dulcis Thunb, a food supplement and traditional medicine used in East Asia, has been demonstrated to exhibit hepatoprotective, antimicrobial, neuroprotective, and anti-oxidant activities. To evaluate the anti-oxidant activities of H.dulcis in STZ-induced diabetic mice, the different extracting solvents were employed to compare the antioxidant activity by the classical Fenton’s reagent, the concentrations of SOD, MDA, and iNOS in the serum were determined. The results showed that the ethanol (70%) exhibited the most effective antioxidant activity and dose-dependently upregulation of SOD and downregulation of MDA and iNOS significantly in STZ-induced diabetic mice. These indicated that H.dulcis displayed remarkable anti-diabetic activity.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 1827-1830
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.1827
• Online since: July 2012
• Authors: Long Huo Wu, Jian Zhang
• Keywords: Anti-Oxidant, H.dulcis, iNOS, MDA, SOD

References

[1] Yoshikawa K, Kondo Y, Kimura E, et al.. Phytochemistry. 1998, 49(7): 2057-2060.

[2] Li G, Min BS, Zheng C, et al.. Arch Pharm Res. 2005, 28(7): 804-809.

[3] Xu FF, Zhang XQ, Zhang J, et al.. J Asia Nat Prod Res. 2012, 14(2): 135-140.

[4] Hyun TK, Eom SH, Yu CY, et al.. Planta Med. 2010, 76: 943-949.

[5] Rahimi R, Nikfar S, Larijani B, et al.. Biomed Pharmacother. 2005, 59(7): 365-373.

[6] Kaneto H, Kajimoto Y, Miyagawa JI, et al.. Diabetes. 1999, 48: 2398 – 2406.

[7] Ji Y, Chen S, Zhang K, et al.. J Chinese Med Mater. 2002, 25(3): 190-191.

[8] Babincova M, Bacova Z, Machova E, et al.. J Med Food. 2002, 5(2): 79-83.

[9] Aksoy N, Vural H, Sabuncu T, et al.. Cell Biochem Funct. 2003, 21(2):121-125.

[10] Abdollahi M, Ranjbar A, Shadnia S, et al.. Med Sci Monit. 2004, 10(6):RA144-RA147.

[11] Nazirog¡lu M, Butterworth P.. Can J Appl Physiol. 2005, 30(2):172-85.

[12] Chanwitheesuk A, Teerawutgulrag A, Rakariyatham N.. Food Chem. 2005, 92:491-497.

DOI: 10.1016/j.foodchem.2004.07.035

[13] Larkins, Nicholas, Wynn S.. Vet Clin North Am Small Anim Pract. 2004, 34(1): 291-327.

[14] Coskun O, Kanter M, Korkmaz A, et al.. Pharmacol Res. 2005, 51:117-23.

[15] Ohnishia M, Matuoa T, Tsunob T, et al.. Biofactors. 2004, 21:315-319.

[16] An SW, Kim YG, Kim MH, et al.. Korean J Med Crop Sci. 1999, 7: 263-268.

[17] Yoo SM, Mun S, Kim JH.. Process Biochem. 2006, 41: 567-570.

[18] Ruan LP, Yu BY, Fu GM, et al.. J Pharm Biomed Anal. 2005, 38: 457-464.