Antimicrobial Activity and Interaction with Bovine Serum Albumin of Nickel(II) Complex

Abstract:

The binding reaction of nickel(II) complex [Ni(C₁₆H₂₀N₂)₂•(H₂O)₂]Cl₂•C₃H₇NO with bovine serum albumin(BSA) was studied by fluorescence spectroscopy under the simulative physiological conditions. The experimental results show that the fluorescence quenching of BSA by nickel(II) complex is a result of the formation of ground state complex and the quenching mechanism was static quenching. The binding constants were 4.24×10³ L•mol⁻¹ at 293K with one binding site. The antimicrobial activity study found that the nickel(II) complex was active against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 1831-1834
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.1831
• Online since: July 2012
• Authors: Yu Fen Liu, Hai Tao Xia, De Fu Rong
• Keywords: Bovine Serum Albumin (BSA), Fluorescence Spectrum, Nickel(II) Complex

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