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Improved Water-Solubility of Phytosterol by Hydroxypropyl-β-Cyclodextrin

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Abstract:

Phytosterol has been shown to lower the serum cholesterol concentrations, but its low solubility in water restricts its application. In this study, hydroxypropyl-β-cyclodextrin was used to improve the water-solubility of phytosterol. Phase solubility study pointed out the formation of 1:1 inclusion complexes between phytosterol and hydroxypropyl-β-cyclodextrin. The initial dissolution rate was remarkedly improved in the first two minutes. The suitable solvent and temperature for complex formation was n-butanol and 40°C.

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Periodical:

Advanced Materials Research (Volumes 554-556)

Pages:

922-925

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.554-556.922

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Online since:

July 2012

Authors:

Xiao Yan Zhang, Yong Peng, Guo Qing He

Keywords:

Hydroxypropyl-β-Cyclodextrin, Inclusion Complex, Phytosterol

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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