Kinetic Resolution of Ethyl-2-hydroxy-4-phenylbutyrate with Lipase AK as Catalyst

Zhi Min Ou; Ren Wei Li

doi:10.4028/www.scientific.net/AMR.560-561.333

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 560-561Kinetic Resolution of...

Kinetic Resolution of Ethyl-2-hydroxy-4-phenylbutyrate with Lipase AK as Catalyst

Abstract:

Ethyl (R)-2-hydroxy-4-phenylbutyrate was prepared by enzyme resolution of racemic ethyl- 2-hydroxy-4-phenylbutyrate. The optimal resolution conditions were 0.074 mol/L ethyl-2-hydroxy-4-phenylbutyrate, 20 mg lipase AK in 2.0 ml ethenylethanoate, 30 0C, 100 rpm. Enantiomeric excess of ethyl (R)-2-hydroxy-4-phenylbutyrate was up to 99%. Kinetic resolution model of ethyl- 2-hydroxy-4-phenylbutyrate by lipase AK was described by double substrate ping-pong mechanism. Model data agreed well with experimental data.

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Periodical:

Advanced Materials Research (Volumes 560-561)

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333-337

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https://doi.org/10.4028/www.scientific.net/AMR.560-561.333

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Online since:

August 2012

Authors:

Zhi Min Ou, Ren Wei Li

Keywords:

Esterification, Ethyl (R)-2-Hydroxy-4-Phenylbutyrate, Kinetic Resolution, Lipase AK

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