A Kinetic Study on the Degradation of Erythromycin A in Acetone Solution with Chemical Technology

Shu Yu Liu; Jia Wen Zhu

doi:10.4028/www.scientific.net/AMR.577.73

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 577A Kinetic Study on the Degradation of Erythromycin...

A Kinetic Study on the Degradation of Erythromycin A in Acetone Solution with Chemical Technology

Abstract:

The purpose of this experiment is to know the stability of erythrocin and determine the rate constant by the study of degradation of erythromycin with chemical technology. HPLC method was used for the determination of erythromycin. The degradation of erythromycin are studied at pH=7,pH=8,pH=9 and pH=10 respectively. Experiment results show that the rate of decline of erythromycin followed by pH=10>pH=9>pH=8>pH=7 in the different pH buffer solution. The rate constants are 0.0022h-1 and 0.0088h-1 at pH=8 and pH=9 respectively.