Preparation and Performance Evaluation of the Analgesic and Anti-Inflammatory Effects of Chitosan Composite Materials

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Abstract:

The author had used salivation method to prepareQuercetin-ornidazole-chitosan composite material (QOCCM) and then used this film to the treatment for the rat model of oral ulcer. and finally found that it can promote the healing of ulcers. In order to investigate the mechanism of action in the treatment of oral ulcers, we prepare Quercetin-ornidazole-chitosan complex solution, and then used the application of carrageenan induced paw edema and croton oil-induced mouse ear swelling to observe its anti-inflammatory role, application of hot plate method to observe the analgesic effect of inflammatory and evaluate the effects of chitosan composite materials.

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171-174

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October 2012

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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[1] GUAN QH , PEI DS , LIU XM , etal . Neurop rotection againstis chemicbrain injury suppressing the extrinsi candint- rinsic pat hways of apoptosis [J] . Brain Res , 2006 , 1092(1): 36-46.

Google Scholar

[2] N EUMAR RW. Molecular mechanism of chemicneuronal injury [J]. Ann Emerg Med , 2000, 36 (5) : 483-506.

Google Scholar

[3] CARDOSOCM , ALMEIDALM , CUSTODIO JB. Protection of Tamoxi-fen against oxidation of mitochondrial thiols and NAD(P) H underlying the permeability transition induced by prooxida nts [J] . Chem Biol Interact , 2004 , 148 (3) : 149-161.

DOI: 10.1016/j.cbi.2004.06.001

Google Scholar

[4] Muzzarelli RA Mattioli-Belmonte M , Pugnaloni A etal. Bioehemistry,histolog and clinieal uses of chitins and chitosansin,in wound healing[J]. EXS,1999, 87(2): 51-61.

DOI: 10.1007/978-3-0348-8757-1_18

Google Scholar