Synthesis and DNA Binding Study of Zinc (II) Co-Ordination Complexes

Abstract:

Since the discovery of cisplatin, transitional metal complexes have been proven to be potent DNA intercalating agents. As zinc being an active core of binding site of some metalloenzymes, the synthesis of structurally similar zinc (II) complexes is on the offing. They are found to be potent DNA intercalating and cleaving agents. Thus, the current study is focused on synthesis of zinc (II) complexes using amino acid / schiff bases as ligands. The complexes are characterized by FTIR, UV-Visible and mass spectral studies and assessed for their DNA binding study using λ DNA by Gel electrophoresis.

• Periodical: Advanced Materials Research (Volume 584)
• Pages: 401-405
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.584.401
• Online since: October 2012
• Authors: Poonam R. Inamdar, Jyotsna Hazarika, T.B. Sridharan, A. Sheela
• Keywords: DNA Binding Study, Metal Complexes, Zinc (II) Complexes

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