Effect of EDA/PEGDGE Mole Ratios on PEG-Based Hydrogel Scaffolds Properties

Zuratul Ain Abdul Hamid; Anton Blencowe; Greg Qiao; Geoff Stevens

doi:10.4028/www.scientific.net/AMR.626.681

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 626Effect of EDA/PEGDGE Mole Ratios on PEG-Based...

Effect of EDA/PEGDGE Mole Ratios on PEG-Based Hydrogel Scaffolds Properties

Abstract:

The synthesis of biocompatible hydrogel based on poly (ethylene glycol) (PEG) and ethylene diamine (EDA) using epoxy-amine chemistry was conducted. PEG was chosen as the base material (or monomer) to synthesise hydrogels in this study due to its high hydrophilicity, biocompatibility and low toxicity properties. The effects of mole ratios of EDA to PEGDGE on the hydrogel scaffolds properties (i.e., gelling time, swelling) were investigated. It was found out for hydrogel scaffolds prepared at 1.2 and 1.4 M [PEGDG and an EDA/PEGDGE mol ratio of 0.5 in DMSO gave the optimum hydrogel properties. Swelling studies has confirmed that hydrogel prepared at 0.5 mole ratios consist of highly cross-linked network as expected.

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Periodical:

Advanced Materials Research (Volume 626)

Pages:

681-685

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.626.681

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Online since:

December 2012

Authors:

Zuratul Ain Abdul Hamid, Anton Blencowe, Greg Qiao, Geoff Stevens

Keywords:

Cross-Linked Hydrogel, Epoxy-Amine Step Growth Polymerization, Hydrogel Scaffolds, Tissue Engineering

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