Preparation and Properties Analysis of Slow-Release Microcapsules Containing Patchouli Oil

Abstract:

Abstract: The microcapsules containing patchouli oil were prepared using a complex coacervation with chitosan and arabic gum as wall material, patchouli oil as the core material. The different factors influence on the microcapsule properties were investigated by scanning electron microscope, laser particle size analyzer, infrared spectrum and UV spectra. The best conditions for preparing patchouli oil microcapsules were confirmed as follows: the concentration of chitosan with low viscosity 0.5%, arabic gum 4%, and the ratio of wall material to core material was 2: 1. The pH value of the complex coacervation reaction was 4.5, and stirring speed was 800 r/min. The microcapsules were analyzed by Infrared spectral to confirm the patchouli oil had been successfully embedded in the microcapsules. The drug loading and encapsulation efficiency for patchouli was 20.7% and 67.2%, respectively.

• Periodical: Advanced Materials Research (Volumes 641-642)
• Pages: 935-938
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.641-642.935
• Online since: January 2013
• Authors: Guang Tao Han, Zi Ming Yang, Zheng Peng, Guang Wang, Min Zhou, Yu Xin Pang, Pu Wang Li
• Keywords: Complex Coacervation, Microcapsule, Patchouli Oil

References

[1] Liu Liangfeng, Huang Xiaodan, Cai Dake, et al. Patchouli and patchouly research. Chinese Journal of Information on TCM. 16(2)(2009).

[2] Zhang Zhongmin, Li Yucui, Peng Shaozhong, et al. Patchoulicalcohol research summaries, Chinese Journal of Information on TCM. 19(1) (2012).

[3] Wei Zengjiang , Wang Chaoyang , Zou Shengwen , Liu Hao, Tong Zhen . Chitosan nanoparticles as particular emulsifier for preparation of novel pH-responsive Pickering emulsions and PLGA microcapsules. Polymer, 53(2012)1229-1235.

DOI: 10.1016/j.polymer.2012.02.015

[4] Shi Xinyuan , Tan Tianwei . Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of Vitamin D2. Biomaterials , 23(2002)4469–4473.

DOI: 10.1016/s0142-9612(02)00165-5

[5] Sunil A. Agnihotri, Nadagouda N. Mallikarjuna, Tejraj M. Aminabhavi*. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. Journal of Controlled Release, 100(2004)5 –28.

DOI: 10.1016/j.jconrel.2004.08.010

[6] Huang Liangliang, Sui Weiping , Wang Yuanxiu , Jiao Qiang . Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil. Carbohydrate Polymers , 80(2010)168-173.

DOI: 10.1016/j.carbpol.2009.11.007

[7] Yang Ziming，Li Li, Yang Zhuohong，et al. Chemical crosslinking method of microcapsule to cotton fabrics with functional finishing. Polymer Materials Science and Engineering, 26(7)(2010)118-121.

[8] Sudipta C, Fabien S, Christine C, Suzy V, et al. Preparation of microcapsules with multi-layers structure stabilized by chitosan and sodium dodecyl sulfate. Carbohydrate Polymers, 90(2012)967–975.

DOI: 10.1016/j.carbpol.2012.06.028