Synthesis and Anti-Tumor Activity of Cyclodepsipeptides Paecilodepsipeptide A

Abstract:

paecilodepsipeptide A was first synthesized by retrosynthesis methods. the structures were determined by Mass Spectrometry and NMR spectroscopy, and the anti-tumor activities on human hepatocellular carcinoma cell line (SMMC-7721) and human lymphoma cell line (Raji) were examined by MTT. The result showed that the rate of Paecilodepsipeptide A was 72% by retrosynthesis methods. The structures of the synthesized product were identified by 1H NMR and 13C NMR spectra, which is identical to the natural product. The product has remarkable anti-proliferation activity on SMMC-7721 and Raji, which showed good anti-tumor activity. IC50 was 8.97 μmol/L and 11.13 μmol/L respectively, The total synthesis of Paecilodepsipeptide A is significant to further study its derivatives and develop novel antitumor drugs.

• Periodical: Advanced Materials Research (Volume 643)
• Pages: 92-95
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.643.92
• Online since: January 2013
• Authors: Ming Jun Yang, Yong Gang Wang, Xiao Feng Liu, Jing Wu
• Keywords: Anti-Tumor, Paecilodepsipeptide A, Total Synthesis

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