Preparation and Evaluation of Chitosin-Coated Alginate/Gelatin Microspheres for Sustained-Release Drug Delivery System In Vitro

Qiang Song Wang; Yuan Lu Cui; Tian Jiao Dong

doi:10.4028/www.scientific.net/AMR.651.227

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 651Preparation and Evaluation of Chitosin-Coated...

Preparation and Evaluation of Chitosin-Coated Alginate/Gelatin Microspheres for Sustained-Release Drug Delivery System In Vitro

Abstract:

The purpose of the study was to prepare and evaluation chitosin-coated alginate/gelatin microspheres for sustained-release drug delivery system in vitro. The microspheres were prepared with an emulsification technique, characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimetry (DSC). The average particle size of the chitosan-coated alginate/gelatin microspheres was uniform. The results of FT-IR and DSC showed that the microspheres were formed by intermolecular cross-linkages between chitosan and gelatin. The results also implied that the microsphere were a practicable dosage form to increase drug loading ratio for the poorly water-soluble drugs by encapsulated with chitosan. In vitro release of the microsphere indicated that it had a satisfactory sustained-release behavior for the sustained-release drug delivery system.

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Periodical:

Advanced Materials Research (Volume 651)

Pages:

227-231

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.651.227

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Online since:

January 2013

Authors:

Qiang Song Wang, Yuan Lu Cui, Tian Jiao Dong

Keywords:

Alginate/Gelatin, Berberine Hydrochloride, Chitosan, Evodiamine, In Vitro, Micro-Sphere, Sustained-Release

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