Evaluating the Properties of an Alginate Wound Dressing for Skin Repair

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Abstract:

The treatment of skin lesions is a costly and complex process, for which different strategies are currently available. In this study, we investigated the properties of novel films composed of alginate and aloe vera gel for application as wound dressing material. The films combine the occlusive and haemostatic properties of calcium alginate gels with the therapeutic properties of aloe vera. We expect that these films may improve the healing process through the release of aloe vera compounds directly into the wound bed and could be an alternative to the administration of synthetic drugs to infected wounds. The films exhibited high transparency in both dry and wet state, as well as adequate mechanical properties for skin use. The results indicated that the films present great potential to be explored as wound dressing material.

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141-144

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April 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] F. Groeber, M. Holeiter, M. Hampel, S. Hinderer, K. Schenke-Layland, Skin tissue engineering – In vivo and in vitro applications, Adv Drug Deliv Rev. 63 (2011) 352-366.

DOI: 10.1016/j.addr.2011.01.005

Google Scholar

[2] V. Jones, J.E. Grey, K.G. Harding, Wound dressings, BMJ. 332 (2006) 777-780.

DOI: 10.1136/bmj.332.7544.777

Google Scholar

[3] R. Pereira, A. Carvalho, D.C. Vaz, M.H. Gil, A. Mendes, P. Bártolo, Development of novel alginate based hydrogel films for wound healing applications, Int J Biol Macromol. 52 (2013) 221-230.

DOI: 10.1016/j.ijbiomac.2012.09.031

Google Scholar

[4] T. Pongjanyakul, S. Puttipipatkhachorn, Alginate-magnesium aluminum silicate films: Effect of plasticizers on film properties, drug permeation and drug release from coated tablets, Int J Pharm. 333 (2007) 34-44.

DOI: 10.1016/j.ijpharm.2006.09.046

Google Scholar

[5] L. Wang, E. Khor, A. Wee, L.Y. Lim, Chitosan-Alginate PEC Membrane as a Wound Dressing: Assessment of Incisional Wound Healing, J Biomed Mater Res. 63 (2002) 610-618.

DOI: 10.1002/jbm.10382

Google Scholar

[6] B. Hansen, G.B.E. Jemec, The Mechanical Properties of Skin in Osteogenesis Imperfecta, Arch Dermatol. 138 (2002) 909-911.

DOI: 10.1001/archderm.138.7.909

Google Scholar

[7] A. Göpferich, Mechanisms of polymer degradation and erosion, Biomaterials. 17 (1996) 103-114.

DOI: 10.1016/0142-9612(96)85755-3

Google Scholar