Medium Optimization for Active Substance Production of Streptomyces alboﬂavus TD-1 Using Response Surface Methodology

Zhi Fang Wang; Hong Zhang; Chang Lu Wang; Zhen Jing Li; Feng Juan Li; Mian Hua Chen; Yu Rong Wang; Yu Fang Huang

doi:10.4028/www.scientific.net/AMR.683.250

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 683Medium Optimization for Active Substance...

Medium Optimization for Active Substance Production of Streptomyces alboﬂavus TD-1 Using Response Surface Methodology

Abstract:

To increase the production of active substances, response surface methodology (RSM) was employed. The results showed that the inoculation size, concentrations of MgSO4•7H2O and KNO3 in medium had signiﬁcant effects on yields of active substances and the ﬁnal values optimized with RSM were 12.75 % inoculation size, 0.34 g/L MgSO4•7H2O and 0.13 g/L KNO3, respectively, which increased 1.96 fold production of active substances in comparison to the production of initial fermentation conditions.

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Periodical:

Advanced Materials Research (Volume 683)

Pages:

250-253

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.683.250

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Online since:

April 2013

Authors:

Zhi Fang Wang, Hong Zhang, Chang Lu Wang, Zhen Jing Li, Feng Juan Li, Mian Hua Chen, Yu Rong Wang, Yu Fang Huang

Keywords:

Activesubstance, Medium Optimization, Response Surface Methodology (RSM)

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