Synthesis and Development of Polymers-Infiltrated Porous Iron for Temporary Medical Implants: A Preliminary Result

Article Preview

Abstract:

Iron has been viewed as a promised biodegradable metal for temporary implants but its slow degradation is considered as the main limitation. Some works have been done to improve its degradation rate including by alloying and by processing through powder metallurgy. This work presents new approach to accelerate the degradation rate of iron by infiltrating biodegradable polymer into the pores of bulk iron foam. Solution of poly(L-lactic-co-glycolic acid) or PLGA was infiltrated into the iron foam by vacuum infiltration method to form PLGA-infiltrated porous iron (PIPI). It was found that the existence of PLGA in the iron foam maintained the mechanical property as that of iron foam. Degradation test has shown that the PLGA lead the degradation in PIPI samples. This preliminary work has shown the potentiality of the incorporation of biodegradable polymers into biodegradable metals for tailoring their degradation rate.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

331-335

Citation:

Online since:

April 2013

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2013 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] M. Peuster, P. Wohlsein, M. Brugmann, M. Ehlerding, K. Seidler, C. Fink, H. Brauer, A. Fischer, G. Hausdorf, A novel approach to temporary stenting: Degradable cardiovascular stents produced from corrodible metal-results 6-18 months after implantation into New Zealand white rabbits, Heart 86 (2001) 563-569.

DOI: 10.1136/heart.86.5.563

Google Scholar

[2] S.N. Kurpad, J.A. Goldstein, A.R. Cohen, Bioresorbable Fixation for Congenital Pediatric Craniofacial Surgery: A 2-Year Follow-Up, Pediatr. Neurosurg. 33 (2000) 306-310.

DOI: 10.1159/000055976

Google Scholar

[3] B.L Eppley, A.M. Sadove, R.J. Havlik, Resorbable plate fixation in pediatric craniofacial surgery, Plast. Reconstruc. Surg. 100 (1997) 1-7.

DOI: 10.1097/00006534-199707000-00001

Google Scholar

[4] H. Hermawan, Biodegradable Metals: From Concept to Applications, Springer, Heidelberg, 2012.

Google Scholar

[5] F. Witte, V. Kaese, H. Haferkamp, E. Switzer, A. Meyer-Lindenberg, C.J. Wirth, In vivo corrosion of four magnesium alloys and the associated bone response, Biomaterials 26 (2005) 3557-3563.

DOI: 10.1016/j.biomaterials.2004.09.049

Google Scholar

[6] X.N. Gu, Y.F. Zheng, A review on magnesium alloys as biodegradable materials, Front. Mater. Sci. China 4 (2010) 111-115.

Google Scholar

[7] H. Hermawan, D. Dubé, D. Mantovani, Degradable metallic biomaterials: Design and development of Fe-Mn alloys for stents, J. Biomed. Mater. Res. 93A (2010) 1-11.

DOI: 10.1002/jbm.a.32224

Google Scholar

[8] M. Schinhammer, A.C. Hänzi, J.F. Löffler, P.J. Uggowitzer, Design strategy for biodegradable Fe-based alloys for medical applications, Acta Biomater. 6 (2010) 1705-1713.

DOI: 10.1016/j.actbio.2009.07.039

Google Scholar

[9] H. Hermawan, H. Alamdari, D. Mantovani, D. Dubé, Iron-manganese: New class of metallic degradable biomaterials prepared by powder metallurgy, Powder Metall. 51 (2008) 38-45.

DOI: 10.1179/174329008x284868

Google Scholar

[10] M. Moravej, F. Prima, M. Fiset, D. Mantovani, Electroformed iron as new biomaterial for degradable stents: Development process and structure-properties relationship, Acta Biomater. 6 (2010) 1726-1735.

DOI: 10.1016/j.actbio.2010.01.010

Google Scholar

[11] L.S. Nair, C.T. Laurencin, Biodegradable polymers as biomaterials, Prog. Polym. Sci. 32 (2007) 762-798.

Google Scholar

[12] S.L. Ishaug-Riley, G.M. Crane, A. Gurlek, M.J. Miller, A. W. Yasko, M.J. Yaszemski,. Ectopic bone formation by marrow stromal osteoblast transplantation using Poly(Dl-lactic-co-glycolic acid) foams implanted into the rat mesentery, J. Biomed. Mater. Res. 36 (1997) 1-8.

DOI: 10.1002/(sici)1097-4636(199707)36:1<1::aid-jbm1>3.0.co;2-p

Google Scholar

[13] H. Hermawan, A. Purnama, D. Dubé, J. Couet, D. Mantovani, Fe-Mn alloys for metallic biodegradable stents: Degradation and cell viability studies, Acta Biomater. 6 (2010) 1852-1860.

DOI: 10.1016/j.actbio.2009.11.025

Google Scholar

[14] C. Park, S.R. Nutt, PM synthesis and properties of steel foam, Mater. Sci. Eng. A 288 (2000) 111-118.

Google Scholar

[15] F.G. Torres, S.N. Nazhat, Md. Sheikh, S.H. Fadzullah, V. Maquet, A.R. Boccaccini, Mechanical properties and bioactivity of porous PLGA/TiO2 nanoparticle-filled composites for tissue engineering scaffolds, Compos. Sci. Technol. 67 (2007) 1139-1147.

DOI: 10.1016/j.compscitech.2006.05.018

Google Scholar