Optimze the Structure of Impeller for Stirred Bioreactor

Li Kuan Zhu; Bo Yan Song; Zhen Long Wang; Yu Kui Wang

doi:10.4028/www.scientific.net/AMR.694-697.148

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 694-697Optimze the Structure of Impeller for Stirred...

Optimze the Structure of Impeller for Stirred Bioreactor

Abstract:

This paper mainly makes comparative analysis on four main types of blade in stirred bioreactor by Computational Fluid Dynamics(CFD) simulation. Firstly we establish simulation method suited for stirred bioreactor, then simulate the velocity and shear force of flow field in the bioreactor. No matter from flow field mixing or shear force aspect, Elephant Ear blades is the most suitable for cell large scale culture. At last, it optimizes the installation method and angle of Elephant Ear blades. It concludes that anticlockwise rotation and 45°installation angle is the optimum.

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Periodical:

Advanced Materials Research (Volumes 694-697)

Pages:

148-153

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.694-697.148

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Online since:

May 2013

Authors:

Li Kuan Zhu*, Bo Yan Song, Zhen Long Wang, Yu Kui Wang

Keywords:

Computational Fluid Dynamics (CFD), Large Scale Culture, Stirred Bioreactor

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* - Corresponding Author

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